1997.9-2001.7,山西大學(xué),化學(xué)教育,理學(xué)學(xué)士;
2001.9-2004.7,山西大學(xué),應(yīng)用化學(xué),工學(xué)碩士,導(dǎo)師:晉衛(wèi)軍教授;
2004.7-2005.8,山西大學(xué),環(huán)境科學(xué)與工程研究中心,助教
2005.9-2008.7,中科院理化所,凝聚態(tài)物理,理學(xué)博士,導(dǎo)師:師文生研究員;
2008.9至今,中科院理化所,歷任助理研究員、副研究員、正高級工程師。
長期從事納米傳感器方面的研究:
(1)基于一維納米結(jié)構(gòu)的單細(xì)胞主動檢測技術(shù);
(2)貴金屬納米團簇的可控制備及在生物分析中的應(yīng)用;
(3)神經(jīng)細(xì)胞監(jiān)測平臺的構(gòu)建及在相關(guān)疾病研究中的應(yīng)用。
先后主持科技部國家重點研發(fā)計劃政府間國際科技創(chuàng)新合作重點專項、中國科學(xué)院前沿科學(xué)重點研究項目子課、中科院青年創(chuàng)新促進會人才項目、國家自然科學(xué)基金青年轉(zhuǎn)面上項目、北京市自然科學(xué)基金面上項目、國家自然科學(xué)基金青年基金等項目,同時作為科研骨干參與科技部重點研發(fā)計劃、中科院重大科研裝備研制項目等多項。
1. Lushan Huang, Liyi Ma, Qiaowen Zhao, Qichen Zhu, Guangwei She, Lixuan Mu,* and Wensheng Shi*,Simultaneous Imaging of pH and Peroxynitrite in the Endoplasmic Reticulum and Mitochondria: Revealing Organelle Interactions in Alzheimer’s Disease Pathogenesis,?Analytial Chemistry, 2025, 97, 194.
2. Qiaowen Zhao, Liyi Ma, Siwei Chen , Lushan Huang , Guangwei She, Yongan Sun, Wensheng Shi*, Lixuan Mu *, Tracking mitochondrial Cu(I) fluctuations through a radiometric fluorescent probe in AD model cells: Towards understanding how AβOs induce mitochondrial Cu(I) dyshomeostasis, Talanta, 2024, 271, 125716.
3. Chenyuan Yan, Lixuan Mu,* ?Mingliang Mei, Yuan Wang, Guangwei She, and Wensheng Shi*,F(xiàn)luorescence Enhancement Method for Aptamer-Templated Silver Nanoclusters and Its Application in the Construction of a β-Amyloid Oligomer Sensor,Analytical Chemistry, 2023, 95, 6915?6922.
4. Yuan Wang, Qiaowen Zhao, ?Sen Liang, Mingliang Mei, Guangwei She, Wensheng Shi* and Lixuan Mu*, Single nanowire-based fluorescence lifetime thermometer for simultaneous measurement of intra-and extra-cellular temperatures, Chemical Communications, 2023, 59, 4483.
5. Mingliang Mei, Lixuan Mu*, Yuan Wang, Sen Liang, Qiaowen Zhao, Lushan Huang, Guangwei She, Wensheng Shi*, Simultaneous Monitoring of the ATP levels in Cytoplasm and Nucleus of a Single Cell with Single Nanowire-Based Fluorescent Bio-sensor, Analytial Chemistry, 2022, 94, 11813-11820.
6. Yuan Wang, Sen Liang, Mingliang Mei, Qiaowen Zhao, Guangwei She, Wensheng Shi,* Lixuan Mu* , Sensitive and stable thermometer based on the long fluorescence lifetime of Au nanoclusters for mitochondria, Analytical Chemistry, 2021, 93, 15072.
7.Mingliang Mei, Lixuan Mu,* Sen Liang, Yuan Wang, Guangwei She, Wensheng Shi, A general configurational strategy to quencher-free aptasensors, Biosensensors and Bioelectronics, 2021, 178, 113025.
8.?Min Chen, Lixuan Mu*, Shuai Wang, Xingxing Cao, Sen Liang, Yuan Wang, Guangwei She, Jun Yang, Yongan Wang, and Wensheng Shi, A Single Silicon Nanowire-Based Ratiometric Biosensor for Ca2+?at Various Locations in a Neuron, ACS Chemical Neuroscience, 2020, 11, 1283-1290.
9.?Congcong Bu, Lixuan Mu*, Xingxing Cao, Min Chen, Guangwei She, Wensheng Shi*. Silver nanowires-based fluorescence thermometer for single cell, ACS Applied Materials & Interfaces, 2018, 10, 33416.
10. Xingxing Cao, Lixuan Mu*, Min Chen, Congcong Bu, Sen Liang, Guangwei She, Wensheng Shi* Single silicon nanowire-based fluorescent sensor for endogenous hypochlorite in an individual cell, Advanced Biosystems, 2018, 1800213.
中科院盧嘉錫青年人才獎、中科院青年創(chuàng)新促進會會員
人才隊伍